BEJELENTKEZÉS

Curriculum Vitae

 

(see also Who's who in France,  America, and Who's who in the World, Who’s Who in Medicine, Science and Technology)

 

ROBERT Ladislas (Leslie , Laszlo)

 

Born in Budapest (Hungary), 1924

 

Cursus:

 

                Faculties of Sciences and Medicine, Szeged, Targu-Mures (Transylvania), Budapest and Paris

 

                M.D., University of Paris: " Action de la température sur les réactions biologiques". Silver Medal

 

                Ph.D., Lille, France :" L'élastine et les élastases".

 

                Scientific carrier:  tenured Member of the French National Research Center (CNRS) since 1950.

 

                Research Director (class 1) since 1974

 

                retired from CNRS, September 1994

 

                1995-1997: Director of the Connective Tissue Research Team in the Department of Cell Biology, Sciences Faculty, University  Paris 7.

 

                Since 1998: Laboratoire de Recherche Ophtalmologique, Faculté de Médecine -Hôtel Dieu, Université Paris 5.

 

                Teaching:           

 

                Undergraduate courses (Masters Degree) in Aging Biology

 

                Graduate courses in Connective Tissue Biochemistry and Aging Biology

 

                Degree of Specialization in Geriatrics - courses in basic Gerontology at several Medical Schools

 

                Director and Supervisor of about 50 Ph.D. Theses

 

                Worked in the following Laboratories

 

                Institute of Biochemistry, Faculty of Medicine, Budapest, Profs R.B.STRAUB and  I. BACH. 1945-1948

 

                Department of Biochemistry, Faculty of Medicine, Paris, Prof. M. POLONOVSKI, Prof. M-F. JAYLE. 1949-1959

 

                Department of Biochemistry, Illinois University School of Medicine, Chicago, USA, Prof. R.J. WINZLER. 1959-1960

 

                Department of Biochemistry, College of Physicians and Surgeons, Columbia University, New-York, USA, Prof. Z. DISCHE. 1960-1961

 

                Institute of Immunology, Hôpital Broussais, Prof. B.N. HALPERN.1962-1966

 

                Founder of the French Laboratory of Connective Tissue  Biochemistry, then  Research Laboratory of the CNRS. 1966-1994, at the Henri Mondor Hospital Medical School, University Paris XII.

 

DISTINCTIONS

 

                Laureate of the Medical School, Paris, 1953

 

                Prize of the Association of Scientific Journal Editors, 1962

 

                Reiss Prize  of Ophthalmology ( with  Prof. Y. POULIQUEN), 1970

 

                Honorary Doctor Degree of the Semmelweis University, Budapest, Hungary, 1991

 

                Verzar Medal for Gerontological Research, University of Vienna (Austria), 1994

 

                Member of the Hungarian Academy of Sciences, 1995

 

Elected corresponding Member of the Scientific Academy of Westfalian-Northern Rhenany (Germany), 1996

 

                NOVARTIS Prize, International Society of Gerontology, 1997

 

                Scientist of the year, French Society of antioxidants, 2008

 

Member of French and Foreign Societies :

 

                               Société de Chimie Biologique et de Biologie Moléculaire, France

 

                               Biochemical Society, UK

 

                               American Chemical Society, USA

 

                               New York Academy of Sciences, USA

 

                               Member of the Scientific Board of the Research Institute on Arteriosclerosis, University of Münster, Germany, 1972-1996

 

                               Founder, General Secretary, President and since 1986, Honorary President of the French Society of Connective Tissue Research

 

                               Founder of the Federation of European Connective Tissue Societies                                                   President  of the French Atherosclerosis Society

 

Member of the Editorial Board of the following reviews

 

                               Journal of Bology

 

                               Atherosclerosis

 

                               Gerontology

 

                               Archives of Gerontology and Geriatrics

 

                               Clinical Physiology and Biochemistry

 

                               Rheumatology

 

                               Pathologie-Biologie

 

Scientific contributions

 

                Books

 

                               Mécanismes Cellulaires et Moléculaires du Vieillissement, Masson, Paris, 1983

 

                               Les Horloges Biologiques, 1989, Flammarion, Paris

 

                               Le vieillissement, de l'Homme aux cellules, 1994, Belin-CNRS

 

                               Le Vieillissement, Faits et Théories, 1995, Dominos-Flammarion, Paris

 

                               Vieillissement du cerveau et démences, 1998, Nouvelle Bibliothèque Scientifique, Flammarion, 2ND ED : 2003

 

                               Les Temps de la Vie, 2002, Nouvelle Bibliothèque Scientifique, Flammarion.

 

                               Bio-Logiques du vieilissement (With PA Miquel), 2004, Kimé , Paris

 

                               Les secrets de la longévité, 2006, Editions Louis Audibert, Paris

 

                Series Editor: "Frontiers of Matrix Biology", Karger, Bâle, 11 Volumes

 

                               Co-Editor (with A.M. Robert): Colloque International n° 287 du CNRS:"Biochimie Normale et Pathologique du Tissu Conjonctif", 2 volumes, 1980

 

                               Co-Editor (with F. DELBARRE et H.KAISER) of "Les maladies du Tissu Conjonctif", 1980 and (with F. DELBARRE et H. GREILING) of" Pharmacologie cellulaire et moléculaire des maladies du Tissu Conjonctif", 1981, Colloques Franco-Allemands de Rhumatologie, Boerhinger-Ingelheim, France

 

                                Co-Editor "Elastin and Elastases", 2 volumes, 1989 CRC Press, Boca Raton, Florida

 

                               Editor : Molecular Biology and Pathology of Elastin, (Ciba Foundation symposium), 1995, Wiley, London

 

Publications  in International Scientific Journals

 

                More than 1000

 

List of publications since 2002.

 

Cell-matrix interactions in cancer spreading - effect of aging;. An introduction.

 

Robert L

 

In Seminars in Cancer Biol. Robert L. (Guest Ed). 2002, 12: 157-16

 

Fibronectin in malignancy. Effect of Aging.

 

Labat-RobertJ

 

Seminars in Cancer Biol. 2002,12 :187-195

 

Les Temps de la Vie.

 

Robert L.

 

 Flammarion, Paris, 2002

 

Regulation of elastase-type endopeptidase activity, MMP-2 and MMP-9 expression and activation in human dermal fibroblasts by fucose and a fucose-rich polysaccharide.

 

Isnard N, Péterszegi G, Robert AM, Robert L

 

Biomed. Pharmacother. 2002,  56: 258-264

 

 Protection de la cornée contre l'effet des protéases. Etude expérimentale d'oligomères procyanidoliques (OPC) sur la cornée bovine.

 

Robert AM, Robert L, Renard G

 

J Fr. Ophtalmol. 2002,205: 351-355

 

Inhibition of cell proliferation and fibronectin biosynthesis by Na ascorbate.

 

Péterszegi G, Dagonet F, Labat-Robert J, Robert L

 

 Eur. J. Clin. Invest . 2002, 32: 372-380

 

Serum elastase activity, serum elastase inhibitors, and occurrence of carotid atherosclerotic plaques.

 

Zureik M, Robert L, Courbon D, Touboul PJ, Bizbiz L, Ducimetière

 

Circulation. 2002,105: 2638-2645

 

 Effect of hyaluronan on matrix metalloproteinase expression in fibroblasts and keratocytes.

 

Isnard N, Legeais JM, Renard G, Robert L.

 

In:  Kennedy JF, Phillips GO, Williams PA Eds. Hyaluronan. Woodhead Pub. Ltd. Vol 1, 2002, pp 531- 535          

 

 Aging and  regulation of hyaluronan biosynthesis, comparatives studies on human skin fibroblasts and corneal keratocytes.

 

                ,Robert L, Fodil I, Isnard N, dupuy F, Robert AM, Renard G.

 

                In:  Kennedy JF, Phillips GO, Williams PA Eds. Hyaluronan. Woodhead Pub. Ltd. Vol 1, 2002,pp 537- 543           

 

Mécanismes et mesure du vieillissement.

 

Robert L.

 

La lettre du Biologiste. 2002, p 2

 

 Elastin, past, present and future.

 

Robert L.

 

Pathol. Biol. 2002, 50: 503-511

 

Modulation of cell-phenotype during in vitro aging. Glycosaminoglycan biosynthesis by skin fibroblasts and corneal keratocytes.

 

Isnard N, Fodil I, Robert L, Renard G

 

Exp. Gerontol. 2002, 37: 1377-1385

 

Cell-elastin interactions :essential results of the first years of research on the elastin-receptor.

 

Robert L., Fülöp T.

 

In :Tamburro AM, Pepe A. Eds. Elastin 2002, EditricHermes . pp139-158

 

Le vieillissement du cerveau.

 

Robert L.

 

 Champs-Flammarion, Paris 2003

 

The mechanisms of aging : from genetic to epigenetic.

 

Robert L., Labat-Robert J. 

 

Presse Médicale .2003,32 :609-618

 

Effect of sulfated GAGs on the expression and activation of MMP-2 and MMP-9 in corneal and dermal explant cultures.

 

Isnard N, Robert L, Renard G.

 

 Cell Biol. Int  2003,27 :779-784

 

Aging- from basic research, clinical gerontology and « anti-aging » medicine. Robert L

 

Biomed Pharmacother, 2003,57 :541-542

 

Aging from basic research to pathological applications.

 

Robert L, Robert AM.

 

 Pathol Biol. 2003,51 :543-549

 

Pharmacological properties of fucose. Applications in age-related modifications of connective tissues.

 

Péterszegi G., Fodil-Bourahla I., Robert AM., Robert L. 

 

Biomed Pharmacother . 2003,57 :240-245

 

The age-dependent vasodilation and endothelial calcium influx induced by elastin peptides are modulated by extracellular glucose level.

 

Faury G, Robert L, Verdetti J.

 

Biomed Pharmacother. 2003, 57 :216-222

 

Effect of L-fucose and fucose-rich oligo- and polysaccharides (FROP-s) on skin aging : penetration, skin tissue production and fibrillogenesis.

 

Fodil-Bourahla I, Bizbiz L, Schoevaert D., Robert AM, Robert L.

 

 Biomed Pharmacother. 2003, 27 :209-215

 

Studies on skin aging. Preparation and properties of fucose-rich oligo-and polysaccharides. Effect on fibroblast proliferation and survival.

 

Péterszegi G, Isnard N, Robert AM, Robert L.

 

 Biomed Pharmacother. 2003,57 :187-194

 

Protection by L-Fucose and fucose-rich polysaccharides against ROS-produced cell death in presence of ascorbate.

 

Péterszegi G, Robert AM, Robert L.

 

Biomed Pharmacother. 2003,57 :130-133

 

Sites cryptiques et matrikines :effects cellulaires des peptides de fibronectine et de laminine.

 

Labat-Robert J.

 

 J. Soc. Biol. 2003,197 : 45-51

 

Le vieillissement entre recherche fondamentale, geriatrie clinique et medecine anti-age.

 

Robert L 

 

Pathol. Biol. 2003, 51 :541-542

 

Age-dependent remodeling of connective tissue :role of fibronectin and laminin.

 

Labat-Robert J

 

 Pathol. Biol. 2003, 51 :563-568

 

Effect of a fucose-rich polysaccharide preparation on the age-dependent evolution of the skin surface micro-relief.

 

Robert C., Robert AM, Robert L

 

Pathol Biol. 2003,51 :586-590

 

 Le » pouvoir « montant des « jeunes vieux ». Rôle de la science.

 

ROBERT L.

 

In : Pouvoir et Vie. Actes de L’Université Européenne de Nice, Juillet 2003, Miquel PA &  Mihali C. Eds. Pp 231-234

 

.Cell-matrix interactions in aging : role of receptors and matricryptins.

 

Labat-Robert J.

 

Ageing. Res. Rev. 2004, 3 : 233-247

 

Effect of L-Fucose and fucose-rich polysaccharides on elastin biosynthesis, in vivo and in vitro.

 

L Robert, I. Fodil-Bouralha, L. Bizbiz, A.M. Robert

 

Biomed.Phamacotherapy. 2004, 58 : 123-128

 

Effects of L-Fucose and fucose-rich oligo- and polysaccharides (FROP-s) on collagen biosynthesis by human skin fibroblasts. Modulation of the effect of retinol, ascorbate and -tocopherol.

 

                L. Robert, I. Fodil-Bouralha, L. Bizbiz, AM Robert

 

                Biomed. Pharmacotherapy . 2004, 58 :65-70

 

Pharmacology of skin aging. Stimulation of glycosaminoglycan biosynthesis by L-fucose and fucose-rich polysaccharides, effect of in vitro of fibroblasts.

 

       N. Isnard, L. Robert

 

       Biomed Pharmacotherapy. 2004, 58 :202-204

 

The elastin-laminin receptor-mediated matrix degradation. Effect of glucose concentration. Role in atherosclerosis.

 

Faury G., J. Verdetti., Fülöp T, Robert L.

 

In : Intern Congress Series 1232 : Atherosclerosis XIII. pp 411-413, 2004

 

Anti-aging medicine: The History.  The three avenues of gerontology: from basic research to clinical gerontology and anti-aging medicine. Another French paradox.

 

L .Robert

 

J Gerontol . Biol Sci .  2004, 59 A,(6) : 540-542.   

 

Mécanismes et mesure du vieillissement.

 

L. Robert

 

      Immuno-analyse & Biologie Spécialisée (IMMBIO). 2004, 19 : 215-218

 

Effect of a preparation containing a fucose-rich polysaccharide on periorbital wrinkles of human voluntaries.

 

C.Robert, A.M. Robert, L. Robert.

 

Skin. Res. Technol. 2004, 10 :16

 

Le « pouvoir » montant des « jeunes vieux ». Rôle de la science.

 

L. Robert

 

In : Miquel PA, Mihali C.. Eds. Pouvoir et vie. Actes de l’université européenne d’été de Nice. Pp 231-234. Idea Design & Print, Klug-Napoca, 2004

 

Mécanismes épigénétiques post-transcriptionnels des régulations des fonctions physiologiques et de leur déclin au cours du vieillissement

 

L. Robert

 

J. Soc. Biol. 2004,198 :257-262

 

Trente ans de fibronectine , rôle dans la transformation maligne et dans le vieillissement

 

J. Labat-Robert

 

J. Soc Biol. 2004,198 :287-291

 

Matrix remodeling and atherosclerosis. Effect of age.

 

L.  Robert

 

In : Razzaque MS Ed. Fibrogenesis, cellular and molecular basis. Landes Bioscience/Eurekah.com, Georgetown and Kluwer Academic/Plenum Pub,NY, chapter  9, pp 104-117 , 2004

 

Negative regulation of corneal elastin biosynthesis

 

N. Isnard, L. Robert, G. Renard.

 

Matrix biology, 2004, 23 :410

 

Mécanismes fondamentaux impliqués dans le vieillissement cellulaire et tissulaire

 

L. Robert

 

In : MM. Denis et Veyssier (Eds) "Vieillissement : les données biologiques". Elsevier, Chapitre 2,

 

Longévité et déclin, mécanismes génétiques etépigénétiques.

 

L. Robert

 

BioFutur, 2005,253 :33-37

 

Les maladies liées à l’âge.

 

L. Robert

 

BioFutur, 2005,253 :39-44

 

The Extracellular Matrix During Normal Development and Neoplastic Growth.

 

J. Labat-Robert, L. Robert

 

In : Progress in Molecular and Subcellular Biology. Macieira-Coelho A Ed.  Development Biology of Neoplastic Growth. Springer Verlag Berlin-Heidelberg, 2005

 

Pp 79-106

 

Presence and active synthesis of the 67 kDa elastin-receptor in human circulating white blood cells

 

A  Larbi,  G  Levesque, L  Robert, D  Gagné,  N  Douziech, T. Fülöp Jr

 

Biochem Biophys Res Comm, 2005,352 :787-792

 

Mécanismes épigénétiques dans le vieillissement. (Mise au point)

 

L.  Robert

 

Alzheimer Actualités (Fondation IPSEN), 2005,180 :8-11

 

 L. Robert

 

Proteases et Vieillissement

 

In : Eléments de prévention du vieillissement pathologique  Collection «            Abrégés de Médecine » ,pp 13-35, 2005, Masson-Elsevier

 

MMP-type endopeptidase activity in the cornea. Its evolution during organ culture storage at the Eye Bank. Effect of hyaluronan.

 

N. Isnard, P. Sabatier, A.M. Robert, L. Robert, G. Renard

 

Pathol. Biol. 2005, 53, 424-429

 

Cell-elastin interaction and signaling.

 

L.  Robert

 

Pathol. Biol. 2005, 53, 399-404

 

Effect of procyanidolic oligomers of Vitis vinifera on the biosynthesis and excretion of corneal glycosaminoglycans.

 

A.M. Robert, L. Robert, G. Renard

 

Pathol. Biol. 2005, 53, 411-415

 

  Introduction : matrix biology in the 21st century. From a static-rheological role to a dynamic-signaling function.

 

J. Labat-Robert, L. Robert

 

Pathol. Biol. 2005, 53, 369-371

 

Elastin peptides induced oxidation of LDL by phagocytic cells

 

T. Fülöp Jr, A. Larbi , A. Fortun, L. Robert, A. Khalil

 

¨Pathol. Biol. . 2005, 53, 416-423

 

Fritz Verzar’s contribution to Experimental Gerontology –An assessment after half a century

 

                L. Robert, I. Zs-Nagy

 

                Arch. Gerontol. Geriatr.

 

Effet d’un polysaccharide riche en fucose (FROP-3) sur le vieillissement cutané. Etude indentométrique sur volontaires humains.

 

          

 

C. Robert, AM Robert, L. Robert

 

J. Med. Esth. Et Chir. Derm, 2005, 32 :269-274

 

952.       Le Vieillssement : du cellulaire à la fonction. Préface.

 

L. Robert.

 

Cahiers de la FIAPA, n°4, Juin 2005, , pp IX-XI

 

Studies on corneal wound healing : effect of Fucose on iodine vapor burnt rabbit corneas.

 

Isnard N, Bourles-Dagonet, Robert L, Renard G.

 

Ophthalmologica  2005;219:324-333

 

Étude de l’effet des oligomères procyanidoliques sur la fibrillogénèse de la cornée

 

Robert AM, Robert L, Renard G.

 

J. Fr. ophtalmol. 2005, 28 : 1017-1025

 

Retard de cicatrisation – Sénescence.

 

L. Robert

 

In : Plaies et cicatrisations. Meaume S, Dzrzurz O, Téot L Eds. Pp 45-48, Masson Paris, 2005.

 

Effect of procyanidolic  oligomers  on corneal

 

 collagens of rabbits treated  by excimer laser photoablation.

 

Robert AM, Salvodelli M, Legeais JM, Robert L, Renard G.

 

Biomedicine & Pharmacol. 2006, 60 :113-120

 

 Effect of high glucose concentration  on corneal collagen biosynthesis

 

Robert L, Menasche M, Robert AM, Renard G.

 

Ophthalmologica  . 2006;220:317-22.

 

Fritz Verzar was born 120 years ago : His contribution to experimental  gerontology  through the collagen research as assessed after half a century

 

Robert L.

 

Arch. Gerontol. Geriatrics. 2006, 43 : 13-43

 

The metabolic syndrome and the Maillard reaction. An introduction.

 

Labat-Robert J, Robert L

 

Pathol Biol . 2006 ,  54 : :371-374.

 

An original approach to aging: an appreciation of Fritz Verzar's contribution in the light of the last 50 years of gerontological facts and thinking.

 

Robert L.

 

Gerontology. 2006; 52:268-74.

 

Pharmacological properties of rhamnose-rich polysaccharides, potential interest in age-dependent alterations of connectives tissues.

 

Andres E, Molinari J, Peterszegi G, Mariko B, Ruszova E, Velebny V, Faury G, Robert L.

 

Pathol Biol . 2006, 54: 420-5.

 

Effect of advanced glycation end-products on cell proliferation and cell death.

 

Peterszegi G, Molinari J, Ravelojaona V, Robert L.         

 

Pathol Biol . 2006, 54: 396-404

 

Protection by rhamnose-rich polysaccharides against the cytotoxicity of Maillard reaction products.

 

Ravelojaona V, Molinari J, Robert L.

 

Biomed Pharmacother. 2006, 60:359-62.

 

Conciliating science, philosophy and religion to better

 

understand aging: an interview with Dr. Ladislas Robert

 

Tamas Fulop

 

Biogerontology 2007, 8: 63–70

 

The Effect of Cell Matrix Interactions and Aging on the Malignant Process.

 

Labat-Robert J, Robert L, In Van de Woude, Klein G. Eds.

 

Adv. Cancer Res. 2007,  98 :  221-259

 

Bourges J-L, Robert AM, Robert L*, Renard G

 

Zonular fibers

 

Pathologie-Biologie, 2007, 55 :347-359

 

 Robert L

 

Le vieillissement, ses mécanismes et ses théories.

 

In :  Miquel PA. ed : Evolution des concepts fondateurs de la biologie du XXIe siècle.

 

DeBoeck, Belgique

 

Robert L.

 

120 Eve Született Verzar Frigyes, a kiserleti gerontologia megalapitoja : Visszatekintés EgFél ÉVSZAZADRA ;

 

Magyar Tudomany. 2007, 3 :320-331

 

                Péterszegi G, Robert AM, Robert L. Renard G.

 

Importance de la réaction de Maillard en ophtalmologie.

 

J. Soc.  Biol. 2007,  201 :209-214

 

Ravelojaona V, Péterszegi G, Molinari J, Gesztesi JL, Robert L

 

Démonstration de l’effet cytotoxique des produits avancés de la glycation (AGE-S)

 

J. Soc. Biol. 2007, 201 : 185-188

 

Robert A.M., Robert CS., Robert L.*

 

Symmetry breaking in biological systems. From molecules to tissues.

 

 Struct Chem ,2007, 18 :899-907

 

DOI 10.1007/s11224-007-9212-8

 

 V. Ravelojaona, L. Robert*,   A-M. Robert

 

Effect of cellular  aging on collagen biosynthesis.

 

II. Collagen synthesis and deposition by a human skin fibroblast strain

 

over 25 passages)

 

 Archiv. Gerontol. Geriatr. (2007), doi:10.1016/j.archger.2007.08.017

 

Archives of Gerontology and Geriatrics 47 (2008), pp. 368-376

 

G. Péterszegi, E. Andrès, J. Molinari, V. Ravelojaona, L. Robert*

 

Effect of cellular aging on collagen biosynthesis. I. Methodological considerations and pharmacological applications

 

Archiv. Gerontol. Geriatr. (2007), doi:10.1016/j.archger.2007.08.019

 

Archives of Gerontology and Geriatrics 47 (2008), pp. 356-367

 

Robert L.

 

Télomères et vieillissement. Rôle dans les maladies liées à l’âge

 

Revue de Gériatrie, 2007, 32 :645-651

 

Ravelojaona V., Robert A.M., Robert L, Renard G.

 

Collagen Biosynthesis in Cell Culture - Comparison of Corneal Keratocytes and Skin Fibroblasts. Effect of Rhamnose-Rich Oligo- and Polysaccharides

 

Pathologie Biologie (2007), doi:10.1016/j.patbio.2007.10.003

 

Pathologie-Biologie, 2007,56 :66-69

 

ROBERT L.*, ROBERT A.M.*, FÜLÖP T.**

 

RAPID  INCREASE  IN  HUMAN   LIFE  EXPECTANCY :  WILL  IT   SOON  BE  LIMITED  BY  THE  AGING  OF ELASTIN ?

 

Biogerontology DOI:10.1007/s10522-007-9122-6

 

Biogerontology. 2008 Apr;9(2):119-133.

 

J. Molinari 1, E. Ruszova 2, V. Velebny 2, L. Robert 1 *

 

Effect of Advanced Glycation Endproducts on Gene Expression Profiles of human dermal fibroblasts..

 

BioGerontology. 2008,9 :177-182

 

BGEN-08-6 (2008), DOI : 10.1007/s10522-008-9129-7

 

 Labat-Robert J

 

La fibronectine plasmatique, marqueur nutritionnel

 

La Revue de Gériatrie, 2008, 33 :175-180

 

Robert L

 

Le vieillissement, ses mécanismes et ses théories.

 

In : Biologie du XXIe Siècle, Evolution des concepts fondateurs (PA.Miquel Ed) de Boeck, & Larcier sa, 2008, Bruxelles, pp 347-368

 

Faury G, Ruszova E., Molinari J. Mariko B, Raveaud S, Velebny V, Robert L

 

The -L–Rhamnose recognising lectin site of human dermal

 

fibroblasts functions as a signal transducer. Modulation of Ca2+

 

fluxes and gene expression.

 

BBA , 2008, 1780 :1388-1394

 

 doi:10.1016/j.bbagen.2008.07.008

 

Robert L, Labat-Robert J, Robert AM

 

Physiology of skin aging. Physiologie du vieillissement cutané

 

Pathol-Biol. Ms. No. PATBIO-D-08-00150

 

 Robert L, Robert AM.

 

Immuno-Inflammatory Athero-Arteriosclerosis Induced by Elastin Peptides. Effect of Age.In : Fulöp T, Francesci C, Hirokawa K, Pawelec G. Eds. Handbook on Immunosenescence. pp 1089-1116. DOI 10.1007/978-1-4020-9062-2_1,Springer Science + Business Media B.V., 2009

 

.Ravelojaona V., Robert A.M., Robert L.

 

EXPRESSION OF SENESCENCE-ASSOCIATED -GALACTOSIDASE BY HUMAN SKIN FIBROBLASTS, EFFECT OF ADVANCED GLYCATION END-PRODUCTS AND FUCOSE OR RHAMNOSE-RICH POLYSACCHARIDES.

 

Arch. Gerontol. Geriatr  (2008), doi :10.1016/j.archger.2007.12.004

 

Arch. Gerontol. Geriatr. (2009), 48 :151-154

 

  Robert L, Robert AM.

 

Protéases et vieillissement. In :  Trivalle C. Ed. Gérontologie préventive. Elsevier-Masson SAS. Paris, 2009, pp 54-60

 

Robert L.

 

Introduction to the special issue of Pathologie-Biologie devoted to aging

 

PATBIO2827

 

Doi 10.1016/patbio.2009.09.005

 

 Robert L

 

The Maillard reaction, its nutritional and physiopathological aspects.

 

PATBIO2828

 

DOI 10.1016/patbio.2009.09.006

 

 Robert L*, Robert AM, Renard G.

 

Biological  Effects  of  Hyaluronan  in  Connective  Tissues, Eye, Skin, Venous Wall. Role in Aging. Effets biologiques de l’hyaluronane dans les tissus conjonctifs, l’œil, la peau, la paroi veineuse. Rôle dans le vieillissement.

 

PATBIO2832

 

DOI 10.1016/j.patbio.2009.09.010

 

PATBIO-D-09-00138.

 

Robert L.

 

The Maillard reaction. From nutritional Problems to Preventive Medicine.

 

PATBIO2826

 

DOI 10.1016/j.patbio.2009.09.004

 

Robert L

 

Elastine et fibres élastiques, vieillissement et pathologie. Une introduction

 

Médecine et longévité

 

DOI 10.1016/j.mlong.2009.10.007

 

10.1016/j.mlong.2009.10.007

 

               

 

Robert L.

 

Le vieillisement cutané. Rôle de l’élastine.

 

Médecine et Longévité.

 

DOI 10.1016/j.mlong.2009.10.009

 

10.1016/j.mlong.2009.10.009

 

               

 

L. Robert٭, J. Labat-Robert, A.M. Robert

 

            Receptors and aging: Dedicated to the memory of Paul Ehrlich

 

            for the 100th anniversary of his Nobel Prize

 

                Arch. Gerontol. Geriatr. 2010, 51: 260-263

 

                doi 10.1016/j.archger.2009.11.013

 

Robert L.

 

The Saga of κ-elastin, or the Promotion of Elastin Degradation Products from “garbage” to Receptor Agonists and Pharmacologically Active Principles.

 

Conn. Tissue. Res. 2010. 51 : 8-13

 

DOI: 10.1080/03008200902855925

 

L.Robert, J.Labat-Robert, A.M.Robert

 

         Genetic, Epigenetic and Posttranslational  Mechanisms of Aging.*

 

           Biogerontology,2010, 11 :387-399

 

           DOI: 10.1007/s10522-010-9262-y

 

 L. Roberta,*, J. Molinarib, V. Ravelojaonaa, E. Andrèsb, A.M. Roberta

 

Age- and passage-dependent upregulation of fibroblast elastase-type endopeptidase activity.  Role of advanced glycation endproducts, inhibition by fucose- and rhamnose-rich oligosaccharides.

 

Archiv. Gerontol. Geriatr. 2010,50 :327-331

 

DOI :10.1016/j.archger.2009.05.006

 

 Robert L, Labat-Robert J, Robert AM.

 

Le vieillissement en pièces détachées et ses conséquences pour la médecine anti-âge.

 

J. Méd. Esth. Et Chir. Derm. 2010, 37 , 146 : 73-79

 

Robert L.

 

Introduction au numéro spécial consacré à la cytogérontologie et son rapport à la gériatrie.

 

Médecine et Longévité. 2010, 2 : 112-113

 

Doi :10.1016/j.mlong.2010.07.006

 

Robert L., Labat-Robert J., Robert AM.

 

Vieillissement cellulaire, télomères et maladies liées à l’âge

 

Médecine et Longévité, 2010, 2 : 151-161

 

Doi :10.1016/j.mlong.2010.07.005

 

Robert L., Mecham R.

 

Tribute to Toni Tamburro

 

Path Biol, 2010, 58 : 239-240

 

 Robert L.

 

Tribute to Torvard Laurent

 

Path. Biol., 2010, 58 : 241

 

G. Faury, J. Molinari, E. Rusova, B. Mariko, S. Raveaud,, P. Huber, V. Velebnyf, A.M. Robert and L. Robert

 

Receptors and aging: Structural selectivity of the rhamnose-receptor on Fibroblasts as shown by Ca2+-mobilization and gene expression profiles

 

Arch. Gerontol. Geriatr. 2011, 53 :106-112

 

DOI : 10.1016/j.archger.2010.05.017

 

Labat-Robert J, Robert L. Pouliquen Y.

 

Les tissus conjonctifs, de l’origine au concept à sa « mutation » en matrice extracellulaire. Application aux tissus oculaires. Contribution à l’histoire des Sciences Médicales.

 

Pathologie Biologie, 2011, 59 :183-186

 

DOI 10.1016/j.Patbio.2011.04.006

 

Robert L., Robert AM.., Labat-Robert J.

 

The Maillard Reaction – Illicite (Bio)chemistry in Tissues and Food.

 

Pathologie Biologie,2011,59(6) :321-328

 

DOI 10.1016/j.Patbio.2011.04.007

 

Robert L., Labat-Robert J., Robert AM.

 

       Physiology of skin aging

 

       Clin Plastic Surg. 2012, 39 :1-8

 

       Doi :10.1016/j.cps 2011.09.006

 

Robert L.

 

Longevity and Aging, Genetic and Postgenetic Mechanisms. Which Target to              Choose for Postponing and Treating Age-related Diseases.

 

        Eur. Geriatr. Medicine. 2012,3 : 61-66

 

      DOI : 10.1016/j.eurger.11.004

 

               

 

Robert L, Labat-Robert J, Robert AM.

 

Longévité et vieilissement. A l’occasion du 110ème anniversaire de la naissance de H. Rubinstein

 

        Journal Med Esth et Chir Derm. 2012, 39, 153 (mars) : 35-42

 

 Robert L., Labat-Robert J., Robert AM.

 

Aging of the Extracellular Matrix.

 

Médecine & Longévité. 2012,

 

DOI : 10.1016/j.mlong.2012.02.003

 

Borel JP, Maquart FX, Robert AM, Labat-Robert J, Robert L.

 

Celebration of t he 50th aniversary of the foundation of hhe French Society for Connective tisue Research. Its short history in the frame of the origin and the development of this discipline.

 

Pathologie Biologie. 2012,60 :2-6

 

DOI10.16/j.patbio ;2011.10.001

 

 Labat-Robert J.

 

Cell-Matrix Interactions, the role of fibronectin and integrins. A survey. Pathologie Biologie. 2012.60 : 15-19

 

DOI :10